Endocrinology and Metabolism

Original Articles

Adrenal Gland Big Data Articles (National Health Insurance Service Database)
Epidemiology and Long-Term Adverse Outcomes in Korean Patients with Congenital Adrenal Hyperplasia: A Nationwide Study: Jung Hee Kim, Sunkyu Choi, Young Ah Lee, Juneyoung Lee, Sin Gon Kim; Endocrinol Metab. 2022;37(1):138-147. Published online February 28, 2022; DOI: https://doi.org/10.3803/EnM.2021.1328

3,360 View
149 Download
8 Web of Science
10 Crossref

Background
Previous studies on the epidemiology and complications of congenital adrenal hyperplasia (CAH) were conducted in Western countries and in children/adolescents. We aimed to explore the epidemiology of CAH, as well as the risk of comorbidities and mortality, in a Korean nationwide case-control study.
Methods
CAH patients (n=2,840) were included between 2002 and 2017 from the National Health Insurance Service database and the Rare Intractable Disease program. CAH patients were compared, at a 1:10 ratio, with age-, sex-, and index year-matched controls (n=28,400).
Results
The point prevalence of CAH patients in Korea was 1 in 18,745 persons in 2017. The annual incidence rate declined between 2003 and 2017 from 3.25 to 0.41 per 100,000 persons. CAH patients were at elevated risk for cardiovascular disease (odds ratio [OR], 1.6; 95% confidence interval [CI], 1.4 to 1.9), stroke (OR, 1.7; 95% CI, 1.3 to 2.0), diabetes mellitus (OR, 2.8; 95% CI, 2.6 to 3.1), dyslipidemia (OR, 2.4; 95% CI, 2.2 to 2.6), and psychiatric disorders (OR, 1.5; 95% CI, 1.3 to 1.6). Fracture risk increased in CAH patients aged over 40 years (OR, 1.4; 95% CI, 1.1 to 1.7). CAH patients were at higher risk of mortality than controls (hazard ratio, 1.6; 95% CI, 1.3 to 2.0).
Conclusion
Our nationwide study showed a recent decline in the incidence of CAH and an elevated risk for cardiovascular, metabolic, skeletal, and psychiatric disorders in CAH patients. Lifelong management for comorbidity risk is a crucial component of treating CAH patients.

Citations

Citations to this article as recorded by

Hyperandrogenism and Cardiometabolic Risk in Pre- and Postmenopausal Women—What Is the Evidence?
Angelica Lindén Hirschberg
The Journal of Clinical Endocrinology & Metabolism.2024; 109(5): 1202. CrossRef
Predictors of Cardiovascular Morbidities in Adults With 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia
Suranut Charoensri, Richard J Auchus
The Journal of Clinical Endocrinology & Metabolism.2024; 109(3): e1133. CrossRef
Case report: Development of central precocious puberty in a girl with late-diagnosed simple virilizing congenital adrenal hyperplasia complicated with Williams syndrome
Eun Young Joo, Myung Ji Yoo, Su Jin Kim, Woori Jang, Ji-Eun Lee
Frontiers in Endocrinology.2024;[Epub] CrossRef
Анализ распространенности и заболеваемости надпочечниковой недостаточностью в мире
М. Ю. Юкина, Н. Ф. Нуралиева, Е. А. Трошина
Ateroscleroz.2023; 18(4): 426. CrossRef
Big Data Research in the Field of Endocrine Diseases Using the Korean National Health Information Database
Sun Wook Cho, Jung Hee Kim, Han Seok Choi, Hwa Young Ahn, Mee Kyoung Kim, Eun Jung Rhee
Endocrinology and Metabolism.2023; 38(1): 10. CrossRef
Long-term cardiometabolic morbidity in young adults with classic 21-hydroxylase deficiency congenital adrenal hyperplasia
Beatrice Righi, Salma R. Ali, Jillian Bryce, Jeremy W. Tomlinson, Walter Bonfig, Federico Baronio, Eduardo C. Costa, Guilherme Guaragna-Filho, Guy T’Sjoen, Martine Cools, Renata Markosyan, Tania A. S. S. Bachega, Mirela C. Miranda, Violeta Iotova, Henrik
Endocrine.2023; 80(3): 630. CrossRef
Serum steroid profile captures metabolic phenotypes in adults with classic congenital adrenal hyperplasia
Chang Ho Ahn, Jaeyoon Shim, Han Na Jang, Young Ah Lee, Sang-Won Lee, Man Ho Choi, Jung Hee Kim
The Journal of Steroid Biochemistry and Molecular Biology.2023; 234: 106374. CrossRef
Long‐term health consequences of congenital adrenal hyperplasia
Riccardo Pofi, Xiaochen Ji, Nils P. Krone, Jeremy W. Tomlinson
Clinical Endocrinology.2023;[Epub] CrossRef
Multiplexed Serum Steroid Profiling Reveals Metabolic Signatures of Subtypes in Congenital Adrenal Hyperplasia
Jaeyoon Shim, Chang Ho Ahn, Seung Shin Park, Jongsung Noh, Chaelin Lee, Sang Won Lee, Jung Hee Kim, Man Ho Choi
Journal of the Endocrine Society.2023;[Epub] CrossRef
Long-Term Outcomes of Congenital Adrenal Hyperplasia
Anna Nordenström, Svetlana Lajic, Henrik Falhammar
Endocrinology and Metabolism.2022; 37(4): 587. CrossRef

Clinical Study
Epidemiology and Prognosis of Pheochromocytoma/Paraganglioma in Korea: A Nationwide Study Based on the National Health Insurance Service: Jung Hee Kim, Hyemi Moon, Junghyun Noh, Juneyoung Lee, Sin Gon Kim; Endocrinol Metab. 2020;35(1):157-164. Published online March 19, 2020; DOI: https://doi.org/10.3803/EnM.2020.35.1.157

7,298 View
176 Download
27 Web of Science
24 Crossref

Abstract PDF PubReader ePub

Background

Pheochromocytomas and paragangliomas (PPGLs) are rare endocrine tumors originating from chromaffin cells. PPGLs are associated with a high mortality rate and several complications. To date, no epidemiological studies have been conducted on PPGLs in Asia. This study aimed to investigate the epidemiology and prognosis of PPGLs in Korea using nationwide data.

Methods

Using the National Health Insurance Service Database, subjects with a principal diagnosis of PPGLs on two or more occasions between 2003 and 2014 who satisfied the operational definition of PPGLs were included. Incidence, prevalence, complications, metastasis, and mortality were investigated.

Results

In total, 1048 subjects with a mean age of 47.6±16.1 years were included. There was no sex preponderance. The overall prevalence of PPGLs was 2.13 per 100,000 persons, and the overall age-standardized incidence rate was 0.18 per 100,000 person-years. Malignant PPGLs accounted for 17.7% (185 of 1,048) of cases, and 94 subjects exhibited metastasis at the time of diagnosis. Among initially non-metastatic PPGLs, 9.5% (nine of 954) eventually metastasized after a mean duration of 78.1±41.4 months. The 5-year survival rates for non-metastatic and metastatic PPGLs at diagnosis were 97% and 84%, respectively. Multivariable Cox regression models adjusted for covariates showed that metastatic PPGLs were associated with a 2.40-fold higher risk of mortality than non-metastatic PPGLs (95% confidence interval, 1.38 to 4.17; P=0.002).

Conclusion

PPGLs are rare in Korea, and the prognosis of these endocrine tumors varies depending on whether they are benign or malignant. This epidemiological study paves the way for further research on PPGLs.

Citations

Citations to this article as recorded by

Big Data Research in the Field of Endocrine Diseases Using the Korean National Health Information Database
Sun Wook Cho, Jung Hee Kim, Han Seok Choi, Hwa Young Ahn, Mee Kyoung Kim, Eun Jung Rhee
Endocrinology and Metabolism.2023; 38(1): 10. CrossRef
Diagnosis and Management of Pheochromocytomas and Paragangliomas: A Guide for the Clinician
Sona Sharma, Lauren Fishbein
Endocrine Practice.2023; 29(12): 999. CrossRef
Pheochromocytoma: a changing perspective and current concepts
Andreas Kiriakopoulos, Periklis Giannakis, Evangelos Menenakos
Therapeutic Advances in Endocrinology and Metabolism.2023;[Epub] CrossRef
Image-Guided Precision Medicine in the Diagnosis and Treatment of Pheochromocytomas and Paragangliomas
Gildas Gabiache, Charline Zadro, Laura Rozenblum, Delphine Vezzosi, Céline Mouly, Matthieu Thoulouzan, Rosine Guimbaud, Philippe Otal, Lawrence Dierickx, Hervé Rousseau, Christopher Trepanier, Laurent Dercle, Fatima-Zohra Mokrane
Cancers.2023; 15(18): 4666. CrossRef
Trends in the incidence of adrenocortical carcinoma and pheochromocytoma/paraganglioma in Taiwan
Chung-Hsin Tsai, Tun-Sung Huang, Shih-Ping Cheng
Formosan Journal of Surgery.2023; 56(5): 147. CrossRef
An open-label, single-arm, multi-center, phase II clinical trial of single-dose [131I]meta-iodobenzylguanidine therapy for patients with refractory pheochromocytoma and paraganglioma
Anri Inaki, Tohru Shiga, Yoshito Tsushima, Megumi Jinguji, Hiroshi Wakabayashi, Daiki Kayano, Norihito Akatani, Takafumi Yamase, Yuji Kunita, Satoru Watanabe, Tomo Hiromasa, Hiroshi Mori, Kenji Hirata, Shiro Watanabe, Tetsuya Higuchi, Hiroyasu Tomonaga, S
Annals of Nuclear Medicine.2022; 36(3): 267. CrossRef
Pheochromocytomas and Abdominal Paragangliomas: A Practical Guidance
Jan Calissendorff, Carl Christofer Juhlin, Irina Bancos, Henrik Falhammar
Cancers.2022; 14(4): 917. CrossRef
Characteristics of Intraoperative Hemodynamic Instability in Postoperatively Diagnosed Pheochromocytoma and Sympathetic Paraganglioma Patients
Jung Hee Kim, Hyung-Chul Lee, Su-jin Kim, Kyu Eun Lee, Kyeong Cheon Jung
Frontiers in Endocrinology.2022;[Epub] CrossRef
Change of Computed Tomography-Based Body Composition after Adrenalectomy in Patients with Pheochromocytoma
Yousun Ko, Heeryoel Jeong, Seungwoo Khang, Jeongjin Lee, Kyung Won Kim, Beom-Jun Kim
Cancers.2022; 14(8): 1967. CrossRef
Systematic Review: Incidence of Pheochromocytoma and Paraganglioma Over 70 Years
Abdul Rahman Al Subhi, Veronica Boyle, Marianne S Elston
Journal of the Endocrine Society.2022;[Epub] CrossRef
Incidence and risk factors for myocardial injury after laparoscopic adrenalectomy for pheochromocytoma: A retrospective cohort study
Ling Lan, Qian Shu, Chunhua Yu, Lijian Pei, Yuelun Zhang, Li Xu, Yuguang Huang
Frontiers in Oncology.2022;[Epub] CrossRef
The Clinical Characteristics of Pheochromocytomas and Paragangliomas with Negative Catecholamines
Lin Zhao, Xiaoran Zhang, Xu Meng, Ting Zhang, Hua Fan, Qiongyu Zhang, Yecheng Liu, Xianliang Zhou, Huadong Zhu
Journal of Clinical Medicine.2022; 11(19): 5583. CrossRef
A midline ectopic paraganglioma
Christina SANT FOURNIER, Matthias FARRUGIA, Kimberley PACE, Christian CAMENZULI, Alexander R. ATTARD
Chirurgia.2022;[Epub] CrossRef
Non-Selective Alpha-Blockers Provide More Stable Intraoperative Hemodynamic Control Compared with Selective Alpha1-Blockers in Patients with Pheochromocytoma and Paraganglioma: A Single-Center Retrospective Cohort Study with a Propensity Score-Matched Ana
Yang Yang, Jie Zhang, Liqun Fang, Xue Jia, Wensheng Zhang
Drug Design, Development and Therapy.2022; Volume 16: 3599. CrossRef
Incidence and Clinical Presentation of Pheochromocytoma and Sympathetic Paraganglioma: A Population-based Study
Andreas Ebbehoj, Kirstine Stochholm, Sarah Forslund Jacobsen, Christian Trolle, Peter Jepsen, Maciej Grzegorz Robaczyk, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Reimar Wernich Thomsen, Esben Søndergaard, Per Løgstrup Poulsen
The Journal of Clinical Endocrinology & Metabolism.2021; 106(5): e2251. CrossRef
Determinants of anxiety and depression among pheochromocytoma patients
Siming Jia, Chengbai Li, Zhuqing Lei, Qiang Xia, Yuqing Jiang
Medicine.2021; 100(3): e24335. CrossRef
Pheochromocytoma and paraganglioma with negative results for urinary metanephrines show higher risks for metastatic diseases
Akiyuki Kawashima, Masakatsu Sone, Nobuya Inagaki, Kentaro Okamoto, Mika Tsuiki, Shoichiro Izawa, Michio Otsuki, Shintaro Okamura, Takamasa Ichijo, Takuyuki Katabami, Yoshiyu Takeda, Takanobu Yoshimoto, Mitsuhide Naruse, Akiyo Tanabe
Endocrine.2021; 74(1): 155. CrossRef
Diagnosis for Pheochromocytoma and Paraganglioma: A Joint Position Statement of the Korean Pheochromocytoma and Paraganglioma Task Force
Eu Jeong Ku, Kyoung Jin Kim, Jung Hee Kim, Mi Kyung Kim, Chang Ho Ahn, Kyung Ae Lee, Seung Hun Lee, You-Bin Lee, Kyeong Hye Park, Yun Mi Choi, Namki Hong, A Ram Hong, Sang-Wook Kang, Byung Kwan Park, Moon-Woo Seong, Myungshin Kim, Kyeong Cheon Jung, Chan
Endocrinology and Metabolism.2021; 36(2): 322. CrossRef
Clinical Presentation and Perioperative Management of Pheochromocytomas and Paragangliomas: A 4-Decade Experience
Thomas Uslar, Ignacio F San Francisco, Roberto Olmos, Stefano Macchiavelo, Alvaro Zuñiga, Pablo Rojas, Marcelo Garrido, Alvaro Huete, Gonzalo P Mendez, Ignacio Cortinez, José Tomás Zemelman, Joaquín Cifuentes, Fernando Castro, Daniela Olivari, José Miguel
Journal of the Endocrine Society.2021;[Epub] CrossRef
Pheochromocytoma
Zhonghua Liu, Junsheng Ma, Camilo Jimenez, Miao Zhang
American Journal of Surgical Pathology.2021; 45(9): 1155. CrossRef
Perioperative hemodynamic instability in pheochromocytoma and sympathetic paraganglioma patients
Jung Hee Kim, Hyung-Chul Lee, Su-jin Kim, Soo Bin Yoon, Sung Hye Kong, Hyeong Won Yu, Young Jun Chai, June Young Choi, Kyu Eun Lee, Kwang-Woong Lee, Seung-Kee Min, Chan Soo Shin, Kyu Joo Park
Scientific Reports.2021;[Epub] CrossRef
Changes in the Nociception Level Index During Surgical Resection of Paragangliomas: A Case Report
Rita Saynhalath, Umar H. Khan, Gijo Alex, Joseph T. Murphy, Peter Szmuk
A&A Practice.2021; 15(11): e01542. CrossRef
Hypertension Cure and Reducing Pill Burden after Adrenalectomy for Endocrine Hypertension of Adrenal Origin: A Comparative Study from an Asian and UK Cohort
Kee Y Ngiam, Ciaran Durand, Titus C Vasciuc, Chia H Tai, Raluca Orpean, Fiona Eatock, Mehak Mahipal, Tan W Boon
World Journal of Endocrine Surgery.2021; 13(1): 9. CrossRef
A Brief Overview of the Epidemiology of Pheochromocytoma and Paraganglioma in Korea
Yun Mi Choi
Endocrinology and Metabolism.2020; 35(1): 95. CrossRef

Review Article

Meta-analysis.: Juneyoung Lee; J Korean Endocr Soc. 2008;23(6):361-378. Published online December 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.6.361

2,226 View
54 Download
21 Crossref

Abstract PDF

No abstract available.

Citations

Citations to this article as recorded by

A Meta-Analytic Approach for Examining the Effects of STEAM Education Programs in South Korea
Hye-Mi Jeong, Hyuksoo Kwon, Sung-Ha Kim
Innovation and Education.2023;[Epub] CrossRef
Carbohydrate Intake and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Prospective Studies
Unhui Jo, Kyong Park
Nutrients.2023; 15(7): 1740. CrossRef
Establishment of Joint Attention and Parental Cues in Interaction between Hearing Parents and Young Children Who are Deaf and Hard-of-Hearing: A Systematic Review and Meta-Analysis
Jinju Kim, Youngmee Lee, Gangeun Lee
Communication Sciences & Disorders.2023; 28(2): 340. CrossRef
Attachment- and Relationship-Based Interventions during NICU Hospitalization for Families with Preterm/Low-Birth Weight Infants: A Systematic Review of RCT Data
Soo-Yeon Kim, Ah Rim Kim
International Journal of Environmental Research and Public Health.2022; 19(3): 1126. CrossRef
Effect of Treatment Adherence Improvement Program in Hemodialysis Patients: A Systematic Review and Meta-Analysis
Hana Kim, I. Seul Jeong, Mi-Kyoung Cho
International Journal of Environmental Research and Public Health.2022; 19(18): 11657. CrossRef
A Review of Clinical Studies for Chinese Medicine Treatment of Idiopathic Thrombocytopenic Purpura Using the CNKI Database
Ji-eun Bae, Jae-won Park, Jun-kyu Lim, Mi-so Park, Jeong-su Hong, Dong-jin Kim
The Journal of Internal Korean Medicine.2022; 43(6): 1045. CrossRef
The Effect of Sagunja Decoction on Functional Dyspepsia - A Systematic Review and Meta-Analysis
Kyong-lim Kim, Yu-ran Je, Kyoung-min Kim
The Journal of Internal Korean Medicine.2021; 42(3): 259. CrossRef
Comparison on Efficacy of Administration Time of Levothyroxine in Patients with Hypothyroidism: A Meta-analysis
Ki Pyo Lee, Young-Mi Ah, Hye Duck Choi
Korean Journal of Clinical Pharmacy.2020; 30(2): 87. CrossRef
Efficacy of Porcine Epidemic Diarrhea Vaccines: A Systematic Review and Meta-Analysis
Hokeun Won, Jeonggyo Lim, Yun Hee Noh, Injoong Yoon, Han Sang Yoo
Vaccines.2020; 8(4): 642. CrossRef
A Systematic Review of Outcomes Research in the Hospital Pharmacists’ Interventions in South Korea
So Young Lee, Eun Cho
Korean Journal of Clinical Pharmacy.2019; 29(3): 193. CrossRef
Meta-analysis of Change in Weight and Heart Rate for Phentermine in Obesity
Yeonju Woo, Hyomi Jeong
Journal of Health Informatics and Statistics.2018; 43(4): 290. CrossRef
Clinical Effectiveness of Traditional Herbal Medicine in the Treatment of Chemotherapy-induced Leukopenia: A Systematic Review and Meta-analysis of Randomized Clinical Trials
Min-serh Kim, Yu-jin Jung, Sang-hoon Hong
The Journal of Internal Korean Medicine.2018; 39(4): 520. CrossRef
Blood Pressure Response to Meditation and Yoga: A Systematic Review and Meta-Analysis
Seong-Hi Park, Kuem Sun Han
The Journal of Alternative and Complementary Medicine.2017; 23(9): 685. CrossRef
Effects of Non-pharmacological Interventions on Primary Insomnia in Adults Aged 55 and Above: A Meta-analysis
Ji Hyun Kim, Pok Ja Oh
Korean Journal of Adult Nursing.2016; 28(1): 13. CrossRef
Trends of Meta-analysis in Upper Gastrointestinal Diseases
Chang Seok Bang, Gwang Ho Baik
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2015; 15(2): 80. CrossRef
Effects of Dignity Interventions on Psychosocial and Existential Distress in Terminally ill Patients: A Meta-analysis
Pok Ja Oh, Sung-Rae Shin
Journal of Korean Academy of Nursing.2014; 44(5): 471. CrossRef
Effects of Psychosocial Interventions on Cortisol and Immune Parameters in Patients with Cancer: A Meta-analysis
Pok Ja Oh, Eun-su Jang
Journal of Korean Academy of Nursing.2014; 44(4): 446. CrossRef
Effects of exercise programs on depressive symptoms, quality of life, and self-esteem in older people: A systematic review of randomized controlled trials
Seong-Hi Park, Kuem Sun Han, Chang-Bum Kang
Applied Nursing Research.2014; 27(4): 219. CrossRef
Meta-analysis of the Effects of Obesity Management Program for Children.
Kyung Suk Sung, Young Mi Yoon, Eun Joo Kim
Child Health Nursing Research.2013; 19(4): 262. CrossRef
A Quality Assessment of Meta-Analyses of Nursing in South Korea
Jung-Hee Kim, Ae-Kyung Kim
Journal of Korean Academy of Nursing.2013; 43(6): 736. CrossRef
The Effect of Patient Education Interventions on Distress, Self-Care Knowledge and Self-Care Behavior of Oncology Patients: A Meta-Analysis
Pok-Ja Oh, Hyeong-Ji Choi
Asian Oncology Nursing.2012; 12(4): 257. CrossRef

First
Prev
Page of 1
Next
Last

Search